DONについて
上記より・・・グルタミン特異的アンタゴニスト!
DON(6-diazo-5-oxo-L-norleucine)
DON is a glutamine-specific antagoniset more potent than Benzimidazoles. DON has potent antitumor activity in vitro and in vivo.
It specifically targets glutamine and also aftects glucose uptake. DON can specificall induce apoptosis in CSCs, ang target metastases. Low daily doses of DON are without toxicity.