mRNAワクチンと関節リウマチ増悪

コロナワクチン(主にmRNAワクチン)は、関節リウマチ増悪のリスク

今までは、増悪のみなどだったが、
他ワクチンとの比較で有意差が出た
原因として明らかだ

心筋炎や生理周期などと同じく、医学的にコンセンサスのある状況へ pic.twitter.com/LUm29lBcVK

— トスターダ (内科医) MD PhD (@tostadas_Md_PhD) August 16, 2023

韓国の医学雑誌の論文

Effects of COVID-19 and Influenza Vaccination on Rheumatic Diseases: Results From a Survey of Patient-Reported Outcomes After Vaccination

Results
We analyzed 601 adults with ARD who received the COVID-19 vaccine, with a mean age of 49.6 years (80.5% female). A total of 255 participants (42.4%) received a complete course of primary vaccination, 342 (56.9%) completed the booster dose, and 132 (38.6%) received a mixed vaccine. The frequencies of AEs (188 [52.2%] vs. 21 [5.8%]; P < 0.001) and disease flares (58 [16.2%] vs. 5 [1.4%]; P < 0.001) after COVID-19 vaccination were significantly higher than those after influenza vaccination. In the risk factor analysis, previous allergic reaction to other vaccines (odds ratio, 1.95; confidence interval, 1.07–3.70; P = 0.034) was the only factor associated with the occurrence of AEs. There was no difference in the post-vaccine responses between the mixed and matched vaccines.

結果：６０１人の成人のコロナワクチン接種者を解析した。　年齢中央値は49.6歳。80.5％が女性。

２５５名が初期投与を完了した。３４２名がブースター接種まで完了した。１３２名がミックスしたワクチン接種を受けた。

Conclusion
The results of the survey of patients with ARD revealed that patient-reported AEs and underlying disease flares after receiving the COVID-19 vaccine were significantly higher than those after the influenza vaccine.